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This albumin association shields the peptide from renal filtration and proteolytic degradation, extending its elimination half-life to approximately 168 h (Figure 3)

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Consequently, inhibition of SLC7A11 by TP53 reduces glutathione synthesis, leading to lipid peroxide accumulation and inducing ferroptosis ( Autophagy, particularly lipid autophagy and Beclin-1-mediated xCT degradation, can precipitate ferroptosis

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